Humalog Insulin ^*

Humalog Insulin (generic name: insulin lispro) is a rapid-acting insulin analog designed to manage diabetes mellitus by controlling high blood sugar levels. It is utilized in both type 1 and type 2 diabetes to improve glycemic control. As a modified form of human insulin, Humalog is engineered to mimic the body’s natural insulin response during meals. Its rapid onset allows it to begin working approximately 15 minutes after administration, peaking around one hour, and maintaining its effect for about two to four hours. This swift action helps manage postprandial blood sugar spikes effectively.

The mechanism of action involves facilitating the uptake of glucose by tissues and reducing glucose production in the liver, thereby lowering blood sugar levels. Humalog’s rapid-acting nature makes it suitable for mealtime dosing, providing flexibility and convenience for individuals managing diabetes.​

For more information on diabetes and its treatments, read our article on the subject.

Dosage and administration

The prescribing physician will specify the dosing regimen based on the patient’s metabolic needs, blood glucose monitoring results, and glycemic control goals, which must be followed closely.

Humalog is typically administered subcutaneously via injection into areas such as the abdomen, thigh, upper arm, or buttocks. It is crucial to rotate injection sites within the same region to minimize the risk of damage.

Humalog is usually taken within 15 minutes before or immediately after a meal to effectively manage postprandial blood sugar levels.

If a dose is missed, it is important to consult with a healthcare provider for guidance. Generally, taking the missed dose as soon as remembered is advised, but if it is close to the time for the next scheduled dose, skipping the missed dose may be recommended to avoid the risk of hypoglycemia. Do not double-dose to make up for a missed dose.​

Storage

Proper storage of Humalog is essential to maintain its efficacy. Unopened Kwikpens should be stored in a refrigerator at temperatures between 36-46°F (2-8°C). They should not be frozen, and any insulin that has been frozen should be discarded.

Once a Kwikpen pen is in use, it can be kept at room temperature, below 86°F (30°C), and should be used within 28 days. Exposure to direct heat and light should be avoided, and insulin should not be used after its expiration date. Always inspect the insulin before use; it should appear clear and colorless.

For more information, read our article on drug storage

Common Questions About Humalog

How does Humalog differ from regular insulin?

Humalog is designed to act more quickly than regular human insulin. It starts working approximately 15 minutes after injection, peaks around one hour, and continues to work for two to four hours, allowing for more flexible meal timing.

Can Humalog be used in an insulin pump?

Yes, Humalog can be used in an insulin pump for continuous subcutaneous insulin infusion. This method provides a steady insulin level and can be adjusted based on individual needs.

How does insulin help manage diabetes?

Insulin plays a critical role in regulating blood sugar levels by enabling glucose to enter cells, where it is used for energy. Without enough insulin, glucose builds up in the bloodstream, leading to hyperglycemia. For individuals with diabetes, especially those with type 1 and advanced type 2, the body either lacks insulin or cannot use it properly. Administering Humalog compensates for this deficiency. Fast-acting insulins are typically used around mealtime to manage the rise in blood sugar that occurs after eating. When properly dosed, insulin therapy helps prevent complications such as nerve damage, kidney failure, and vision loss