Metformin is used as a first line treatment of type 2 diabetes in people who are overweight. It is used when diet and exercise have failed to control blood sugar levels. It can also be used in combination with other antidiabetic medicines to provide better control of blood sugar. Metformin in Israel is only available as a 850mg slow release tablet.
The more common side effects of metformin include:
- heartburn.
- stomach pain.
- nausea or vomiting.
- bloating.
- gas.
- diarrhea.
- constipation.
- weight loss.
Type 2 Diabetes Mellitus
Adjunctive therapy to diet and exercise to improve glycemic control in adults with type 2 diabetes
Monotherapy or with sulfonylurea
Immediate-release tablet or solution
- Initial: 500 mg PO q12hr or 850 mg PO qDay with meals; increase dose in increments of 500 mg/week or 850 mg q2Weeks on the basis of glycemic control and tolerability
- Maintenance: 1500-2550 mg/day PO divided q8-12hr with meal
- Not to exceed 2550 mg/day
Extended-release tablet or suspension
- 500 mg PO qDay with dinner; titrate by 500 mg/day qWeek; not to exceed 2000 mg/day
Type 2 Diabetes Prevention (Off-label)
850 mg PO qDay
Target dosing: 850 mg PO q12hr