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For visual reference only; actual product may vary

  • US Name:

    Mirapex

  • Alternative Names:

    Sifrol

  • Active Ingredients:

    Pramipexole

  • Brand Manufacturer:

    Boehringer

  • Manufacturer Location:

    Germany

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Mirapex *

For visual reference only; actual product may vary

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Mirapex is a dopamine agonist prescribed to treat Parkinson’s Disease and Restless Legs Syndrome (RLS).

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Mirapex / Sifrol (generic name: pramipexole) is prescribed to treat symptoms of Parkinson’s Disease. It can also be used to treat Restless Legs Syndrome (RLS).  Parkinson’s Disease is a progressive condition that results from the degeneration of neurons in the basal ganglia in the brain. These neurons use the neurotransmitter dopamine to control movement and coordination. As they deteriorate, dopamine levels decrease, leading to the symptoms of movement disorders commonly associated with Parkinson’s Disease. This condition has no cure, and treatments are designed to relieve the symptoms as much as possible. Restless Legs Syndrome (RLS) is a sleep disorder in which symptoms are experienced when resting or trying to sleep. It is also a movement disorder because people with RLS feel a strong need to move their legs as the only way to relieve their discomfort.  Treatment of Parkinson’s Disease and Restless Legs Syndrome can be based on drugs in the dopamine agonist class, which affect neurons that have dopamine receptors. Unlike other medications, such as levodopa, which acts as a precursor to dopamine itself, the effect of dopamine agonists is to activate the receptors rather than to increase dopamine levels. They are also known as dopamine mimics because they mimic the effect of dopamine without converting levodopa into dopamine. In general, dopamine agonists are less effective than levodopa combined with carbidopa in treating symptoms like bradykinesia and muscle rigidity. However, they are more effective in treating the motor symptoms of Parkinson’s Disease that are affecting movement control. Dopamine agonists such as Mirapx are effective in reducing moderate to severe symptoms of Restless Legs Syndrome when taken at night. Levodopa plus carbidopa may be effective when used intermittently but is usually not prescribed for daily use because long-term use can eventually worsen symptoms.

Dosage

Information on this website does not replace talking with a healthcare professional. Doctors prescribe this medication because they have judged that the benefits outweigh the risk of side effects. The treating doctor will determine the dosage, which may start at a low level and gradually increase based on the patient’s medical condition and response to treatment. Mirapex can be taken with or without food, but taking it with food may lessen nausea. Swallow the tablet whole with water—do not chew, split, or crush it. The doctor may start with a smaller dose of Mirapex daily, adjusting it every five to seven days until the symptoms are under control. The typical daily maintenance dose is 1.5 mg, which may need further increase. Don’t stop using Mirapex without consulting a doctor. Stopping the use of this drug may cause withdrawal symptoms such as anxiety, depression, confusion, fever, and stiffness. This is more likely after the use of pramipexole in high doses or for a long time. Tell a doctor or pharmacist if symptoms of withdrawal occur.

Caution

If a person or their family notices unusual urges or cravings, it’s essential to inform their doctor. These urges might involve behaviors that are out of the ordinary and difficult to resist, potentially causing harm to oneself or others. These behaviors fall under impulse control disorders and may include addictive gambling, excessive eating, overspending, an abnormally high sex drive, or a strong focus on sexual thoughts.

Storage

Store Mirapex in the original package to protect it from moisture.  Store below 77°F/25°C. For more tips on properly storing medication, read Conquer the Chaos: Top Tips for Safe and Organized Medicine Storage.

FAQ

Why do restless legs only happen at night?
Dopamine levels naturally decline by day’s end, possibly contributing to the worsening of restless legs syndrome symptoms in the evening and at night.
Can I test myself for Parkinson’s?
No, Parkinson’s disease is identified through a neurological assessment, reaction to dopamine treatments, and several subsequent appointments.
What time of day are Parkinson’s symptoms worse?
Symptoms of Parkinson’s disease may vary during the day, worsening at specific times like early morning or late evening. This is often due to medications wearing off between doses. Parkinson’s doesn’t result in episodes or flare-ups.

This text is for informational purposes only. Please consult a doctor or pharmacist before using any medication. 

Read the information leaflet that comes with the medication.

Most people who use Mirapex do not experience any adverse side effects. Doctors prescribe this medication because they assess the benefits of such treatment outweigh any likely unwanted effects.

Some of the common but mild side effects are muscle spasms or muscle weakness; sleepiness, dizziness, confusion, or memory problems; weakness; dry mouth, nausea, constipation, or increased urination; or insomnia and unusual dreams. If these persist or worsen, consult with a doctor or pharmacist.

When rising from a sitting or lying position, get up slowly to reduce any feeling of dizziness or lightheadedness.

There are rare but more serious side effects. If it feels like you are fainting, experience mood changes such as confusion, agitation, or hallucinations, have strong and unusual desires (gambling or sexual urges), sudden difficulty moving or walking, feel muscle cramps or spasms, swelling of the ankles or feet, feel chest pain, fever, unusual heartbeat, changes in the frequency of urination or vision changes, go at once to an emergency healthcare facility, taking the package of medication with.

Please bear in mind that not all possible side effects can be listed. If you experience any of these or other unexpected side effects, seek medical attention from a physician.

Parkinson’s Disease. Early signs often include mild symptoms like tremors, commonly beginning in one hand and spreading to other limbs, reduced movement speed (bradykinesia), muscle tightness, limb stiffness, and issues with balance and posture.

There are no specific blood tests, imaging, or other routine tests to detect Parkinson’s Disease. It typically starts with subtle symptoms such as tremors, which usually begin in one hand but progress to affect all of the extremities. These symptoms can combine with slow movement (bradykinesia), muscle rigidity and limb stiffness, or postural instability and balance problems.

A clinical diagnosis is primarily based on medical history, assessment of symptoms, and a neurological examination. If a final diagnosis cannot be reached, a more complex specialized imaging test (DaTscan) that looks at the dopamine in the brain may be necessary.

Restless legs syndrome (RLS): Symptoms typically arise in the late afternoon or evening, intensifying at night and hindering sleep. RLS makes falling asleep and returning to sleep after being woken difficult. Moving legs or walking reduces the discomfort, but typically, the sensations recur soon after movement stops. Relief comes from moving the legs or walking, yet the sensations often return once movement ceases. Diagnosing restless legs syndrome doesn’t rely on a single test. Symptoms, medical and family history, physical exam, and test findings will guide the diagnosis.

  • Is pramipexole a sedative?
    Sifrol (pramipexole) is a dopamine agonist that mimics the neurotransmitter dopamine's effects. It is used to treat Parkinson's Disease and Restless Legs Syndrome. It may cause spontaneous sedation.
  • Is pramipexole a muscle relaxer?
    Pramipexole is not a muscle relaxant. Its role is to help improve movement control for people with Parkinson's Disease or restless legs syndrome (RLS) whose symptoms are primarily poor muscle control. Mirapex is the only version of pramipexole that is approved to treat both Parkinson's and RLS.
  • Can pramipexole be used for sleep?
    Mirapex treats restless legs syndrome (RLS), in which patients feel a strong urge to move their legs. Symptoms usually occur at night. This medication decreases the symptoms and can thereby improve sleep.
  • What happens if I take too much pramipexole?
    Effects of an overdose of pramipexole can include sleepiness, dizziness, nausea and vomiting, headache, insomnia, hallucinations, and behavioral changes. If any of these occur, go straight to an emergency care center.
  • Can I drink alcohol while taking pramipexole?
    Alcohol can increase the side effects of pramipexole and cause symptoms of dizziness, sleepiness, and difficulty focusing. Avoid or limit the use of alcohol while being treated with Mirapex.

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