Stendra ^*

Stendra / Spedra (generic name: avanafil) is a prescription medication approved for the treatment of erectile dysfunction (ED) in adult men. ED is characterized by the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Stendra belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors, which also includes sildenafil, tadalafil, and vardenafil. Avanafil works by inhibiting the PDE5 enzyme, which leads to an increase in cyclic guanosine monophosphate (cGMP) levels. Elevated cGMP causes relaxation of smooth muscle in the corpus cavernosum, allowing increased blood flow to the penis, resulting in an erection when combined with sexual stimulation. One of the notable features of Stendra is its rapid onset of action, with some men achieving erections in as little as 15 minutes after ingestion. By inhibiting the PDE5 enzyme, Stendra enhances erectile function by increasing blood flow to the penis during sexual stimulation. This mechanism addresses the physiological aspect of ED, thereby improving the ability to achieve and maintain an erection suitable for sexual activity. It is important to note that sexual stimulation is required for Stendra to be effective, as the medication does not induce an erection without it. Clinical studies have demonstrated the efficacy of avanafil in improving erectile function across various populations, including men with diabetes and those who have undergone prostatectomy.  Patients should be cautious about excessive alcohol consumption when taking Stendra, as both alcohol and PDE5 inhibitors can lower blood pressure, leading to potential adverse effects such as dizziness or fainting. Visit the Mayo Clinic website for more detailed information on erectile dysfunction and its treatments.

Dosage and Mode of Administration

Stendra is administered orally in tablet form. The typical starting dose is 100 mg, taken as needed approximately 15 to 30 minutes before sexual activity. Based on individual response and tolerability, the dose may be increased to a maximum of 200 mg or decreased to 50 mg. It is recommended not to exceed one dose within a 24-hour period. Stendra can be taken with or without food; however, ingestion with a high-fat meal may delay its onset of action. There is no need to take Stendra on a regular dosing schedule; it should be used only as needed before sexual activity. Therefore, missing a dose is not typically applicable.

Storage Guidelines

Stendra should be stored at room temperature, between 68-77°F (20-25°C). The medication must be kept in its original packaging to protect it from light and moisture. The tablets should not be stored in bathrooms or other damp areas, as moisture can affect the medication’s integrity.

Common Questions About Stendra

How does Stendra work to treat erectile dysfunction?

Stendra (avanafil) is a phosphodiesterase type 5 (PDE5) inhibitor used to treat erectile dysfunction (ED). It functions by blocking the PDE5 enzyme, leading to increased levels of cyclic guanosine monophosphate (cGMP). Elevated cGMP causes relaxation of smooth muscle in the corpus cavernosum inside the penis, allowing increased blood flow during sexual stimulation, resulting in an erection. Stendra is known for its rapid onset of action, with some men achieving erections in as little as 15 minutes after ingestion. However, sexual stimulation is necessary for Stendra to be effective, as the medication does not induce an erection without it.

Can Stendra be taken with other medications?

Stendra should not be used in combination with nitrates or guanylate cyclase stimulators, as this can cause a dangerous drop in blood pressure. Additionally, caution is advised when taking Stendra with alpha-blockers or other antihypertensive medications, as the combination may lead to symptomatic hypotension. It’s essential to inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions. Do not start using any new dietary supplements without first checking with a doctor for possible conflicts.

How does avanafil compare to other PDE5 inhibitors?

Avanafil is a newer PDE5 inhibitor with a rapid onset of action, allowing for more spontaneity in sexual activity. Clinical studies have demonstrated its efficacy in improving erectile function across various populations, including men with diabetes and those who have undergone prostatectomy. Its selectivity for the PDE5 enzyme contributes to a favorable side effect profile, with common adverse effects being mild to moderate and transient in nature.